structures， from geosciences， electronics， biomedicine， and beyond. Many of these systems are characterized by complex nonlinear behavior coupling multiple physical processes over a wide range of length and time scales. Mathematical and computational models of these systems often contain numerous uncertain parameters， One of the greatest challenges in computational science and engineering today is how to combine complex data with complex models to create better predictions. This challenge cuts across every application area within CSE， chemical systems， and astrophysics to engineered systems in aerospace， making high-reliability predictive modeling a challenge. Rapidly expanding volumes of observational data—along with tremendous increases in HPC capability—present opportunities to reduce these uncertainties via solution of large-scale inverse problems. ， transportation， biological systems。
materials，。