95% CI = 1.12–4.95) and toxaphene (OR = 2.20。
4-D (OR = 3.80， 95% CI = 1.12–2.48). Risk of leukemia was associated with exposure to the pesticides mancozeb (OR = 2.35， granulocytic). Odds ratios were calculated by stratification and by unconditional logistic regression. Risk for all LHC was elevated in workers cultivating vegetables (OR = 1.67， extra nodal) and by leukemia histology (lymphocytic，4-D was associated with an increased risk of NHL. ， Agricultural risk factors for lymphohematopoeitic cancers (LHC) in Hispanic farm workers in California were examined in a nested case–control study embedded in a cohort of 139，000 ever members of a farm worker labor union in California. Methods: Crop and pesticide exposures were estimated by linking county/month and crop specific job history information from union records with California Department of Pesticide Regulation pesticide use reports during the 20-year period prior to cancer diagnosis. Results: A total of 131 LHC diagnosed in California between 1988 and 2001 were included in the analysis. Analyses were conducted by gender and subtype of non-Hodgkins lymphoma (nodal， 95% CI=1.85–7.81). Risk of leukemia was particularly elevated among female workers and for granulocytic versus lymphocytic leukemia for several chemicals. No associations were noted for multiple myeloma. Conclusions: California farm workers employed where mancozeb and toxaphene were used had an increased risk of leukemia compared to farm workers employed elsewhere. Employment in farms using 2， 95% CI = 1.04–4.65) while NHL risk was increased in association with 2，。