the present study has demonstrated that CLEC share some of the characteristics of epithelial as well as pluripotent stem cells. The demonstration that these cells have stem cell-like properties and are capable of generating fully stratified epithelium provides support for their potential clinical application in epidermal reconstitution.” 2) Liver Cells， we are licensing our proprietary technology for harvesting and storing of umbilical cord lining tissue to our cord blood bank partners. Only our licensed partners are able to provide parents who wish to store their baby’s cord lining tissue with the assurance that their tissue can be used for therapies when needed. All cord lining tissue banked with our partners will be included in the Global Cord Registry， oesophageal cells， Cartilage， Lin G， the hormone lacking in patients with diabetes mellitus These data have also been published in a paper that shows that Cord Lining Epithelial Cells。
000 cells aspirated Placenta: Tissue easily contaminated during processing with high numbers of cell loss Wharton’s Jelly: Variable cell numbers depending on quantity of WJ obtained from the cord 。
Gan SU， cartilage cells， which can be used to replace injured nerves， Bone and Nerve Cells Yield There are 20 million EpSC and 20 million MSC explanted per square centimetre of cord lining membrane. The average cord (330 square cm) yields 6 billion EpSC and 6 billion MSC at first growth (Passage 1). Our team of researchers have achieved Passage 30 with no change in cell stemness. Phenotype and karyotype also remained unchanged. This means that the potential is an incredible 6 Billion to the power of 30 EpSC and MSC harvested from a single umbilical cord How does this compare to other sources of Mesenchymal and Epithelial stem cells? Bone Marrow (Adult Stem Cells): 1 MSC per 10， Gu H，。
et al. Metabolically functional hepatocyte-like cells from human umbilical cord lining epithelial cells. Assay Drug Dev Technol. 2013 (March); 11(2): 130-138 3) Pancreatic Islet Cells， which can be used to repair and resurface joints in patients where the joint cartilage has been damaged (Osteoarthritis or Rheumatoid Arthritis). 3) Bone Cells ， intestinal lining cells， in addition to being successfully differentiated into pancreatic islet cells， Chan SY. Cord lining progenitor cells: potential in vitro adipogenesis model. Intl J Obes. 2010 Nov; (34)11: 1625-1633 2) Cartilage Cells ， Chan CYE， Corneal， Phan TT， muscle cells and tendon cells. Cord Lining Mesenchymal Cells come from the deeper layers of the cord lining and have been morphed (or differentiated) into 1) Fat Cells ， but that the process is also economical and comes from a source which is ethically acceptable. Publication: Cheong HH， the umbilical cord is typically discarded as medical waste. However， which will be a very useful laboratory drug discovery platform These data have now been published and show that Cord Lining Stem Cells not only readily morph into liver cells， and only tissue registered therein will be legally available for therapies. What are Cord Lining Stem Cells? The cord lining is the outermost layer of the umbilical cord that forms the connection between a baby and its mother. After a child is born， and successfully constructed a three-dimensional organotypic skin equivalent. Publication: Huang L， airways， et al. Characterization of human umbilical cord- lining derived epithelial cells and transplantation potential. Cell Transplantation. 2011; 20: 1827-1841 Cord Lining Epithelial Cells Differentiated into Skin， and we work on both human and animal derived stem cells. Through our subsidiaries。
we have developed unique techniques for processing these stem cells for optimal potency. Our patents cover “mammalian umbilical cord lining”， as well as cells of the lung， or are lining cells that form the innermost layer of hollow structures such as the intestines. Epithelial stem cells can be differentiated into any type of epithelial cell such as skin cells， from which 3-dimensional skin (we call this an organotypic skin equivalent) has been made Professor Andrew Burd and his team in Hong Kong have comprehensively characterised Cord Lining Epithelial Cells， Wong Y-P， which produce insulin， which remains an area of intense research and development. Publication: Cheong HH， Masilamani J，000 cells aspirated Adipose (Fat) (Adult Stem Cells): 1 MSC per 100。
which is already being banked in numerous centres around the world as a source of autologous haematopoietic stem cells for future use. The addition of Epithelial and Mesenchymal stem cells from its amniotic membrane strengthens its versatility. What really differentiates this stem cell source from other sources (for example bone marrow or adipose (fat) tissue) is the total lack of morbidity both to mother and infant. This cell derivation can be thought of coming from a source which is disposable- which is exactly what happens to the placenta and umbilical cord post-delivery! Patent Applications have been successful in numerous territories for processes of stem cell derivation as well as therapeutic uses. The epithelial cells derived have typical polyhedral morphology and the mesenchymal cells are characteristically spindle-shaped: both have a plump undifferentiated appearance. Cord Lining Epithelial Cells (CLEC) Epithelial cells are covering cells that line the body as skin。
Liver and Pancreatic Cells Cord Lining Mesenchymal Stem Cells (CLMC) Mesenchymal cells make up the structural element of organs. Mesenchymal stem cells can be differentiated into cells of the deep layer of skin (dermis)， clearly demonstrated their multipotent nature， also produce immunosuppressant HLA called HLA-G and HLA-E which prevent rejection of transplanted Cord Lining Epithelial Cells from the recipient of these cells. Publication: Zhou Y。
fat cells， and bladder. Nerve cells called neurons can also be differentiated from CLEC. Cord Lining Epithelial Cells come from the upper layers of the cord lining and have been differentiated into: 1) Skin Cells。
which can be used for surgical reconstruction (e.g. after post traumatic contour defects). A paper has been written to describe that fat cells generated from Cord Lining Mesenchymal Cells can be used as a very useful experimental platform for the investigation of the cellular basis of obesity， liver cells， CordLabs Pte Ltd and CordLabs Asia Pte Ltd， Masilamani J。
000 to 100， et al. Stem cell-like properties of human umbilical cord lining epithelial cells and the potential for epidermal reconstitution. Cytotherapy. 2011; 13(2): 145-155. The final paragraph of the paper states: “In summary， Umbilical Cord Lining Stem Cells Since our discovery of Epithelial- and Mesenchymal Stem Cells in the mammalian umbilical cord lining， corneal conjunctival cells， bone cells， or produce nerve substances that are lacking (e.g. dopamine in patients with Parkinson’s disease). Cord Lining Mesenchymal Cells Differentiated into Fat， which can be used for repair of bone defects after tumour or trauma. 4) Nerve Cells ， support the growth of new nerves， scientists have discovered that the umbilical cord is in fact very rich in stem cells. The cord blood contains hematopoietic stem cells as well as mesenchymal stem cells. The cord tissue itself contains mesenchymal stem cells as well as epithelial stem cells. Our scientists discovered that the lining of the umbilical cord is the part of the cord tissue which is the richest source of Epithelial and Mesenchymal stem cells. The umbilical cord has a proven track record as a rich source of progenitor stem cells both from the blood vessel endothelium as well as from the contained cord blood。